Where women’s health meets advanced biology.

Women deserve health interventions that are grounded in rigorous research and informed by data.  That’s why science is the backbone of everything we create.

We develop solutions that work at the biological core of ovarian function, uncovering cellular processes that actually matter. Women deserve interventions that are rooted in research and data. 

Ovarian vitality is essential to whole-body health. Cléova Origin is a targeted intervention formulated to support ovarian function at its source*.

Rooted in Science.

Developed to support ovarian health at the cellular level, targeting key biological processes influencing egg quality and ovarian function over time* .

Designed for Where You Are.

Integrating the state-of-the-art scientific discoveries and clinical insights to meet you where you are in your stage of womanhood.

Whole-Life Vitality.

Going beyond symptom management, focused on the fundamental biology to support cellular stress resilience, metabolic fitness and long-term wellbeing.*

Proactive & Non-Hormonal.

A simple, non-hormonal approach to help women take control of their health timeline.
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Rooted in Science.

Developed to support ovarian health at the cellular level, targeting key biological processes influencing egg quality and ovarian function over time* .

Designed for Where You Are.

Integrating the state-of-the-art scientific discoveries and clinical insights to meet you where you are in your stage of womanhood.

Whole-Life Vitality.

Going beyond symptom management, focused on the fundamental biology to support cellular stress resilience, metabolic fitness and long-term wellbeing.*

Proactive & Non-Hormonal.

A simple, non-hormonal approach to help women take control of their health timeline.
shop now

Cléova Origin promotes the ovaries’ own anti-aging mechanism*.

A foundational biological mechanism for cellular resilience and aging

Your body relies on natural signaling molecules to stay energized, repair cellular damage, and protect organ functions as you age. One of the most important of these is hydrogen sulfide (H₂S), which plays a central role to maintain this biological resilience over time. Modern aging research shows that the biological level of sulfide is critical regulating across the major hallmarks of aging1.It is especially important for ovarian cells, supporting reproductive and hormonal functions over time.  Mechanistically, it supports key processes involved in energy production, cellular repair, and protection against oxidative damages, making it essential and necessary for sustaining cellular quality as the body ages.

Why the Ovary is Especially Vulnerable

The ovaries are among the most metabolically active and stress-sensitive systems in the body.  Ovarian aging begins decades before other organ systems show functional changes, even under the best of health, and is further accelerated in women suffering from various health and environmental conditions. Cells in our ovaries, such as eggs and follicular cells are highly metabolically active, long-lived, and exceptionally sensitive to oxidative stress, inflammation, and metabolic inefficiencies.[1]

Aging of the ovaries leads to significant hormonal, tissue, and cellular changes (including decline in oocyte quantity and quality), leading to functional changes far beyond fertility. It reshapes our bone, muscle, cardiovascular, metabolic, and brain health over time, and ultimately affects overall wellbeing and personal freedom[2].

Cléova’s Approach: Promoting the ovaries’ own stress resilience and defense mechanism*.

Cléova Origin helps support the body’s key control systems that regulate internal levels of sulfide and other metabolites, helping maintain healthy balance in the ovaries and overall health.

Through extensive research and proprietary formulation development [patent pending], we identified a way to support this system using specifically selected, synergistically formulated ingredients.

Cléova Origin is built on a purposefully selected combination of ingredients designed to target key biological systems in synergy to support ovarian health, guided by proprietary research and technologiesˆ.

L-ergothioneine

A naturally occurring compound that enhances cellular resilience and antioxidant balance in metabolically active tissues including the ovaries.

Pyridoxine (Vitamin B6 precursor)

Vitamin B6 precursor which plays a key role in enzymatic processes that maintain cellular redox integrity and metabolic balance.

Glycine

A crucial amino acid that supports cellular homeostasis, amino acid balance, and key metabolic pathways providing healthy cellular states.

Taurine

A natural compound that bolsters cellular stress response and leverages beneficial microbiome activity for ovarian health.

ˆPatent pending

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science at the source. formulated for women. science at the source. formulated for women. science at the source. formulated for women. science at the source. formulated for women.

Jamie Zhan, PhD, MPH

Founder

Christopher Hine, PhD

Scientific Co-Founder

Abraham Nick Morse, MD, MBA

Board Medical Director

David Keefe, MD

Scientific Advisor

Douglas Brubaker, PhD

Scientific Advisor

Kevin Munnelly, MBA

Scientific Advisor

Robert Clay, MBA

Scientific Advisor

Jan Scicinski, PhD

Scientific Advisor

Jayati Aggarwal, PhD

Director, R&D

Kevin Calloway, MBA

Director, Operations

References

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease
[1] Kobayashi, H., Yoshimoto, C., Matsubara, S. et al. Altered Energy Metabolism, Mitochondrial Dysfunction, and Redox Imbalance Influencing Reproductive Performance in Granulosa Cells and Oocyte During Aging. Reprod. Sci. 31, 906–916 (2024). https://doi.org/10.1007/s43032-023-01394-7
Myrthe A J Smits, Bauke V Schomakers, Michel van Weeghel, Eric J M Wever, Rob C I Wüst, Frederike Dijk, Georges E Janssens, Mariëtte Goddijn, Sebastiaan Mastenbroek, Riekelt H Houtkooper, Geert Hamer, Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction, Human Reproduction, Volume 38, Issue 11, November 2023, Pages 2208–2220, https://doi.org/10.1093/humrep/dead177
Weicheng Tang, Kaichen Wang, Yourong Feng, Kuan-Hao Tsui, Keshav K Singh, Michael B Stout, Shixuan Wang, Meng Wu, Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence, Life Medicine, Volume 4, Issue 1, February 2025, lnaf004, https://doi.org/10.1093/lifemedi/lnaf004
Liu, C., Zuo, W., Yan, G. et al. Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy. Nat Aging 3, 670–687 (2023). https://doi.org/10.1038/s43587-023-00419-9
Wu, et al., Hallmarks of ovarian aging, Trends in Endocrinology & Metabolism,
36 (5) 418-439, 2025, https://doi.org/10.1016/j.tem.2025.01.005.
[2] Recognizing the importance of ovarian aging research. Nat Aging 2, 1071–1072 (2022). https://doi.org/10.1038/s43587-022-00339-0. Image Link Here.